Comparison
Anti-aging serum comparison: which active class for which skin
A "best serum" list tells you nothing unless you know what is in the bottle. This comparison puts the five relevant active classes side by side: what each one does, where it stops and which skin it suits.
The five active classes side by side
- Peptides (GHK-Cu, Argireline, Matrixyl): build structure, no irritation, need 8–12 weeks
- Retinol: strongest effect on cell turnover, but an adjustment phase, flaking, and not for pregnancy
- Vitamin C: antioxidant and brightener, unstable, often irritating because of the acidity
- Hyaluronic acid: instant smoothing through water binding, but no structural remodelling
- Niacinamide: regulates oil and redness, barely touches deep lines
How to actually judge a serum
- The active sits high in the INCI list, not below the fragrance
- Concentration, or at least the active class, is stated
- The pH matches the active (copper peptides need a different range than vitamin C)
- Light-protected packaging, a dropper rather than an open jar
- No known incompatible actives crammed into one bottle
Which class for which goal
Fine lines and loss of firmness: peptides. Congestion, breakouts, pigment: retinol or vitamin C. Dehydration lines and dullness: hyaluronic acid plus niacinamide. Sensitive or reactive skin that cannot tolerate retinol: peptides are the only route without an irritation phase.
Where LIORA sits in this comparison
EDNF25070922 belongs in the peptide column: GHK-Cu for collagen, Argireline for expression lines, plus the 5-peptide complex and 24K gold. No retinol, no acids — which is why it can be used nightly, but also why it is not an exfoliant. If you want fast peeling action, you need a different product.
All of it in one formula
EDNF25070922 combines GHK-Cu, bio microneedling, the 5-peptide complex and 24K gold in a single serum.
View the serumFrequently asked questions
- Which serum works best on wrinkles?
- No single serum is best for every skin. For firmness and structure without irritation, peptides are the first choice; for cell turnover, retinol — if your skin tolerates it.
- Can I combine several serums?
- Yes, but not all in the same step. Vitamin C in the morning, peptides at night; alternate retinol and peptides on different evenings.
- How long should I trial a serum before judging it?
- At least 8 weeks. Texture and glow shift earlier, but structural remodelling needs a full skin renewal cycle.