Peptide glossary
Matrixyl (Palmitoyl Pentapeptide-4)
Matrixyl is the trade name for palmitoyl pentapeptide-4, a signal peptide with a fatty-acid anchor. It mimics a collagen fragment and tells skin to build new collagen and hyaluronic acid.
- INCI name
- Palmitoyl Pentapeptide-4
- Also known as
- Palmitoyl pentapeptide-4, Palmitoyl pentapeptide-3, Matrixyl 3000
How it works
The palmitoyl tail improves uptake through the stratum corneum. In the dermis the pentapeptide pushes fibroblasts to produce collagen I and IV, fibronectin and hyaluronic acid — skin reads as denser and plumper.
Layering
- Complements GHK-Cu: different pathways, same goal
- Well tolerated, usable daily on sensitive skin
- Effect is cumulative over 8 to 12 weeks
All of it in one formula
EDNF25070922 combines GHK-Cu, bio microneedling, the 5-peptide complex and 24K gold in a single serum.
View the serumFrequently asked questions
- What is Matrixyl?
- Matrixyl is the brand name of palmitoyl pentapeptide-4, a signal peptide that mimics a collagen fragment and thereby triggers new collagen and hyaluronic acid production.
- Can Matrixyl and GHK-Cu be combined?
- Yes. Both are signal peptides with different targets, so they complement each other in one formula or in the same routine.