Peptide glossary
Signal peptide
A signal peptide is a peptide that prompts skin cells to produce structural proteins. It mimics the fragments released when collagen breaks down, which skin reads as a repair order.
- Also known as
- Matrikine, Collagen signal peptide

Typical signal peptides
- GHK-Cu (copper tripeptide-1): collagen I and III, elastin, wound healing
- Palmitoyl pentapeptide-4 (Matrixyl): collagen I and IV, hyaluronic acid
- Palmitoyl tripeptide-1: collagen signalling in the dermis
How they differ from other peptide classes
Signal peptides build. Neurotransmitter-inhibiting peptides such as Argireline or SNAP-8 relax expression instead. The two groups act at different points and can be combined.
All of it in one formula
EDNF25070922 combines GHK-Cu, bio microneedling, the 5-peptide complex and 24K gold in a single serum.
View the serumFrequently asked questions
- What is a signal peptide?
- A signal peptide is a short peptide that prompts fibroblasts in the skin to build new collagen, elastin or hyaluronic acid.
- Which signal peptides have the best evidence?
- GHK-Cu is the most studied signal peptide, followed by palmitoyl pentapeptide-4 (Matrixyl).